They are extensively used in the treatment of cardiovascular diseases. Antilipid drugs are also categorized into two types: fibrates and statins. Their active metabolite, clofibric acid, is actually a stereo isomer to the herbicide mecaprop (MCPP; 2-[4-chloro-2-methylphenoxy]propionic acid) and has been detected in various Swiss lakes by a group that was strictly looking at herbicide contamination in water (Buser et al., 1998a). They impose their effect by decreasing the plasmatic content of cholesterol and triglycerides. Statins were discovered in extracts of filamentous fungi. They have a characteristic polyketide portion and a hydrohexahydronaphthalene system to which various side chains connect at the... The most widely used antilipemic drugs listed in Table 1.5 act by inhibiting the synthesis of cholesterol in the liver. Cholesterol modulates the fluidity of membranes in eukaryotes and is an important precursor of steroid hormones such as progesterone, testosterone, estradiol, and cortisol. It comes from the food we eat but can also be synthesized de novo in eukaroytes from acetate when acetate is converted to acetyl-CoA and the abbreviated pathway is displayed in the pathway underneath.

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